Communication between a person from one culture and people from another culture with an emphasis on the individual and presence is called intercultural communication. From the Islamic point of view, this topic has the capacity to be studied and researched, because Islam is an important cultural pillar of Iran and is itself a comprehensive program of human life. Fitrah (Nature), meaning the way of divine creation of man, has been one of the main concepts of Islamic anthropology. The main problem of this article is to discover some implications of the theory of nature in intercultural communication. The data collection method is documentary and library, and its analysis method is analytical-inferential and research implication. The implications of the theory of nature in intercultural communication in this research are: 1- language; It is a natural thing and nature itself is also a language of communication between man-man and man-God; 2- religion; It is based on nature, and nature plays a prominent role in inter-religious communication; 3- Paying attention to the principle of free will, lack of self-esteem, paying attention to the value of oneself and others, respect and logical speech are among the important categories from the point of view of nature in negotiation and dialogue; 4- The common identity between all human beings is nature, for this reason, this common identity provides the basis for extensive global intercultural communication; 5- One of the characteristics of truth-seeking nature and paying attention to the right aspects of a culture in intercultural communication; 6- Nature has a prominent role on the individual and the change of structures in cultural contact and cultural change, and 7- The role of nature in cross-cultural communication and the general course of human history is that it moves the world towards evolution.